Triblock peptide–oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

Andrea D. Merg; Ryan V. Thaner; Soumitra Mokashi-Punekar; SonBinh T. Nguyen; Nathaniel L. Rosi

doi:10.1039/C7CC07708D

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Triblock peptide–oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials†

Andrea D. Merg,

^a Ryan V. Thaner,^b Soumitra Mokashi-Punekar,

^a SonBinh T. Nguyen

*^b and Nathaniel L. Rosi

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA, USA
E-mail: nrosi@pitt.edu

^b Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, USA
E-mail: stn@northwestern.edu

Abstract

Triblock peptide–oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.

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Article information

DOI: https://doi.org/10.1039/C7CC07708D
Article type: Communication
Submitted: 06 Oct 2017
Accepted: 19 Oct 2017
First published: 23 Oct 2017

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Chem. Commun., 2017,53, 12221-12224

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Triblock peptide–oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

A. D. Merg, R. V. Thaner, S. Mokashi-Punekar, S. T. Nguyen and N. L. Rosi, Chem. Commun., 2017, 53, 12221 DOI: 10.1039/C7CC07708D

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Chemical Communications

Triblock peptide–oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials†

Abstract

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Triblock peptide–oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

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