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Training the Fetal Immune System Through Maternal Inflammation—A Layered Hygiene Hypothesis.

Publication: Journal Article

Apostol, April C., Kirk D. C. Jensen, and Anna E. Beaudin. 2020. “Training the Fetal Immune System Through Maternal Inflammation—A Layered Hygiene Hypothesis.”. Frontiers in Immunology 11 (123).

Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

Publication: Journal Article

Jensen, Kirk D. C., Xiaoqin Su, Sunny Shin, Luke Li, Sawsan Youssef, Sho Yamasaki, Lawrence Steinman, et al. 2008. “Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ”. Immunity, no. 29(1): 90-100.

Variation in CD8 T cell IFNγ differentiation to strains of Toxoplasma gondii is characterized by small effect QTLs with contribution from ROP16

Publication: Journal Article

Kongsomboonvech, Angel K., Laura García-López, Ferdinand Njume, Felipe Rodriguez, Scott P. Souza, Alex Rosenberg, and Kirk D. C. Jensen. 2023. “Variation in CD8 T Cell IFNγ Differentiation to Strains of Toxoplasma Gondii Is Characterized by Small Effect QTLs With Contribution from ROP16”. Frontiers in Cellular and Infection Microbiology.

Both maternal IFNγ exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells

Publication: Journal Article

López, Diego A, Kelly S Otsuka, April C Apostol, Jasmine Posada, Juan C Sanchez-Arcila, Kirk D C Jensen, and Anna E. Beaudin. 2023. “Both Maternal IFNγ Exposure and Acute Prenatal Infection With Toxoplasma Gondii Activate Fetal Hematopoietic Stem Cells”. The EMBO Journal.

Ahmadzakaria Arjmand

Person: 22'-23', Undergaduate researcher

Ahmadzakaria is interested in CD8 T cell responses to T. gondii infection.

Andrew Curd

Person: ’16-’17 Research Associate, Vera Therapeutics, Inc

Litzy Lemus

Person: 22'-23' Undergaduate researcher

Litzy, a CAMP scholar, worked on the role of T cell help in the antibody response to Toxoplasma gondii.

Samantha Splitt

Person: Masters '16-'17, Precision for Medicine

Our work on genetic mapping of immunity to T. gondii is published in PLOS Pathogens

News: December 06, 2021

Check our out publication in PLOS Pathogens. From a genetic mapping experiment, we determine that Nfkbid is central for the antibody response to T. gondii. Both B-1 and B-2 cells are required for the immunity observed to T. gondii. This is Scott Souza's thesis work and in performed in collaboration...

Scott Souza obtains his Ph.D.!

News: July 16, 2021

Scott Souza successfully defended his Ph.D. He is largely responsible for our lab's current interogation into B cell responses, which required him to explore new models in the lab. We are very proud of all he has accomplished! His publication on his thesis work will be forthcomming.