Evolution and recombination of the plasmidic qnr alleles
Baquirin, Mia HC, and Miriam Barlow. 2008. “Evolution and Recombination of the Plasmidic Qnr Alleles”. Journal of Molecular Evolution 67 (1): 103–110.
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Experimental prediction of the evolution of ceftazidime resistance in the CTX-M-2 extended-spectrum beta-lactamase
Welsh, Kerry J, Miriam Barlow, Fred C Tenover, James W Biddle, Kamile Rasheed, Leigh Ann Clark, and John E McGowan. 2005. “Experimental Prediction of the Evolution of Ceftazidime Resistance in the CTX-M-2 Extended-Spectrum Beta-Lactamase”. Antimicrobial Agents and Chemotherapy 49 (3): 1242-44.
GeneHunter, a transposon tool for identification and isolation of cryptic antibiotic resistance genes
Salipante, Stephen J, Miriam Barlow, and Barry G Hall. 2003. “GeneHunter, a Transposon Tool for Identification and Isolation of Cryptic Antibiotic Resistance Genes”. Antimicrobial Agents and Chemotherapy 47 (12): 3840-45.
Jinah Choi
Research
Our research focuses on the evolution of antimicrobial resistance. Antimicrobial resistance is a serious problem affecting thousands of lives each year. Recent outbreaks of Methicillin Resistant Staphylococcus aureus (MRSA) have illustrated the severity of the resistance problem. Reports in the popular press (New York Times, Oct 16, 2007) have identified MRSA as a greater health threat than HIV. However, the health threats posed by MRSA are only a small fraction of the antimicrobial resistance problem. The causative agents of deadly diseases such as tuberculosis and pneumonia are also becoming resistant to nearly all existing antibiotics as well. Our lab is investigating several approaches to combat the threat of resistance.
Collaborators
Extracellular stress and lipopolysaccharide modulate Acinetobacter baumannii surface-associated motility
McQueary, Christin N, Benjamin C Kirkup, Yuanzheng Si, Miriam Barlow, Luis A Actis, David W Craft, and Daniel Zurawski V. 2012. “Extracellular Stress and Lipopolysaccharide Modulate Acinetobacter Baumannii Surface-Associated Motility”. Journal of Microbiology 50 (3): 434-43.
Ethanol and Reactive Species Increase Basal Sequence Heterogeneity of Hepatitis C Virus and Produces Variants With Reduced Susceptibility To Antivirals
Choi, Jinah, Scott Seronello, Jessica Montanez, Kristen Presleigh, Thu Vo, Seung Bum Park, and Miriam Barlow. 2011. “Ethanol and Reactive Species Increase Basal Sequence Heterogeneity of Hepatitis C Virus and Produces Variants With Reduced Susceptibility To Antivirals”. Free Radical Biology and Medicine, no. 51: S27.
High rate of mobilization for blaCTX-Ms
Barlow, Miriam, Rebecca A Reik, Stephen D Jacobs, M\ onica Medina, Matthew P Meyer, John E McGowan Jr, and Fred C Tenover. 2008. “High Rate of Mobilization for BlaCTX-Ms”. Emerging Infectious Diseases 14 (3): 423.