Zavala J, Robles-Saucedo F, Guerrero-Beltran C, Davila L, Valdez-Garcia J. In Vitro Biocompatibility Panel for PEGDA Intraocular Drug Delivery Devices. Investigative Ophthalmology & Visual Science. 2022;63(7):4157.
zavala_et_al_2022_arvo_63.pdf52.21 KB
Abstract
PEGDA drug delivery devices (PDDD) have potential for the treatment of chronic vitreoretinal diseases, surpassing the ocular barriers, and sustaining the drug release. In vivo models are the most used to analyze the potential of PDDD. However, there are cellular biomarkers that can be analyzed in vitro to prevent non desired effects in preclinical studies. Here, we analyzed the acute cell response in vitro in terms of cell viability, cytotoxicity, apoptosis, and necrosis in cells exposed to PDDD.