Ahmadzakaria Arjmand
Ahmadzakaria is interested in CD8 T cell responses to T. gondii infection.
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Research
In the Jensen laboratory, we study the immunology and pathogenesis of the obligate intracellular parasite Toxoplasma gondii, the causative agent of human toxoplasmosis. Toxoplasma has been dubbed the “ubiquitous” parasite because it infects all species of mammals, a variety of birds and a third of...
Editor's Pick mBio - paper on the GPI of T. gondii
Our paper is published on the GPI sidechain of T. gondii. This is the first description of the entire GPI sidechain synthetic pathway for any eukaryotic microbe generated by two enzymes we named PIGJ and PIGE. This is Julia Alvarez' PH.D. dissertation in collaboration with Chris West at University...
Forward Genetics in Apicomplexa Biology: The Host Side of the Story
Sanchez-Arcila, Juan C, and Kirk D. C. Jensen. 2022. “Forward Genetics in Apicomplexa Biology: The Host Side of the Story”. Frontiers in Cellular and Infection Microbiology 12 (878475).
Training the Fetal Immune System Through Maternal Inflammation—A Layered Hygiene Hypothesis.
Apostol, April C., Kirk D. C. Jensen, and Anna E. Beaudin. 2020. “Training the Fetal Immune System Through Maternal Inflammation—A Layered Hygiene Hypothesis.”. Frontiers in Immunology 11 (123).
Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ
Jensen, Kirk D. C., Xiaoqin Su, Sunny Shin, Luke Li, Sawsan Youssef, Sho Yamasaki, Lawrence Steinman, et al. 2008. “Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ”. Immunity, no. 29(1): 90-100.
Variation in CD8 T cell IFNγ differentiation to strains of Toxoplasma gondii is characterized by small effect QTLs with contribution from ROP16
Kongsomboonvech, Angel K., Laura García-López, Ferdinand Njume, Felipe Rodriguez, Scott P. Souza, Alex Rosenberg, and Kirk D. C. Jensen. 2023. “Variation in CD8 T Cell IFNγ Differentiation to Strains of Toxoplasma Gondii Is Characterized by Small Effect QTLs With Contribution from ROP16”. Frontiers in Cellular and Infection Microbiology.
Both maternal IFNγ exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells
López, Diego A, Kelly S Otsuka, April C Apostol, Jasmine Posada, Juan C Sanchez-Arcila, Kirk D C Jensen, and Anna E. Beaudin. 2023. “Both Maternal IFNγ Exposure and Acute Prenatal Infection With Toxoplasma Gondii Activate Fetal Hematopoietic Stem Cells”. The EMBO Journal.