Welcome to The Merg Lab!
Research within the Merg Lab focuses on the design and fabrication of nanoscale materials derived from the self-assembly of sequence-programmable biomolecules (e.g., peptides, proteins, and nucleic acids). Developing these supramolecular architectures with hierarchical control across length-scales will afford materials that are suitable for a variety of biomedical and bioengineering applications. The Merg Lab is highly interdisciplinary with research interests spanning the fields of peptide chemistry, materials chemistry, supramolecular chemistry, materials science, and bioengineering.
- "Interhelical E@g-N@a Interactions Modulate Coiled Coil Stability within a De Novo Set of Orthogonal Peptide Heterodimers"
- "Hidden structure in disordered proteins is adaptive to intracellular changes"
- "Shape-Shifting Peptide Nanomaterials: Surface Asymmetry Enables pH-Dependent Formation and Interconversion of Collagen Tubes and Sheets"
- "2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks"
- "Seeded Heteroepitaxial Growth of Crystallizable Collagen Triple Helices: Engineering Multifunctional Two-Dimensional Core-Shell Nanostructures"
- "Ligand Exchange for Controlling the Surface Chemistry and Properties of Nanoparticle Superstructures"