Welcome to The Merg Lab!
Research within the Merg Lab focuses on the design and fabrication of nanoscale materials derived from the self-assembly of sequence-programmable biomolecules (e.g., peptides, proteins, and nucleic acids). Developing these supramolecular architectures with hierarchical control across length-scales will afford materials that are suitable for a variety of biomedical and bioengineering applications. The Merg Lab is highly interdisciplinary with research interests spanning the fields of peptide chemistry, materials chemistry, supramolecular chemistry, materials science, and bioengineering.
Recent Publications
- Interhelical E@g-N@a Interactions Modulate Coiled Coil Stability within a De Novo Set of Orthogonal Peptide Heterodimers
- Hidden structure in disordered proteins is adaptive to intracellular changes
- Shape-Shifting Peptide Nanomaterials: Surface Asymmetry Enables pH-Dependent Formation and Interconversion of Collagen Tubes and Sheets
- 2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks
- Seeded Heteroepitaxial Growth of Crystallizable Collagen Triple Helices: Engineering Multifunctional Two-Dimensional Core-Shell Nanostructures
- Ligand Exchange for Controlling the Surface Chemistry and Properties of Nanoparticle Superstructures